In the 1890s, the sons of a strong-willed Jewish woman make their way on the streets of Brooklyn, where they learn about life and laughter.
Brothers Moe and Shemp Howard join their pal, Larry Fine, to become The Three Stooges, which takes them from the stages of vaudeville to the heights of movie stardom, thought not without a cast change.
Through the 1930s, the Stooges star in wildly popular movie shorts laden with slapstick; Curly's off-screen adventures jeopardize the group's success.
As the group's fame soars, Curly's downward spiral becomes more evident, despite the Stooges' packed schedule and talented team.
Shemp rejoins the group, infusing their performance with new life; television's popularity spreads and the Stooges are along for the ride.
A new face joins the Stooges as they leave Columbia Pictures; tensions grow in the Howard family as change looms yet again.
Television brings the Stooges a new surge of popularity, leading them to work with Frank Sinatra, Ed Sullivan and other TV icons.
The world says goodbye to Larry and Moe, but the Stooges' legacy lives on as a new generation meets the comics on the Internet.