Simon, Sioux and Mbali face a global snake crisis; as cities continue to grow and temperatures rise, thousands of snakes are on the move in a desperate search for food, water and shelter, which has led to a spike in snakebites.
In the height of black mamba season, the team splits up to deal with all the calls; Sioux and Mbali face a black mamba while Simon wrestles a big specimen solo.
Simon and Sioux continue to train their apprentice, Mbali, before they head to the snake capital of the world; Snake Shyam, a local catcher, needs help due to the monsoon season in the Indian city of Mysore.
The crew attempts to remove a massive 2.5-meter black mamba that has taken an apartment block hostage. Sioux uncovers another one at a wedding venue, but this time, she must catch it alone.
Mbali attempts to catch her first black mamba; Simon and Sioux travel to India to rescue some deadly snakes.
During a visit to India, snake wrangler Simon Keys dives underwater for a cobra; he rescues the biggest Russell's viper he has ever seen.