Following two Harkonnen sisters as they combat forces that threaten the future of humankind and establish the fabled sect that will become known as the Bene Gesserit.
Tula tries to understand the origins of the nightmare that affects all acolytes of the sisterhood; as Tula attempts to understand the acolytes' shared dream, Valya sets her plan in motion to redeem House Harkonnen ahead of the Landsraad.
As Corrino names a new Bashar, a Sister with deep connections to the Emperor arrives on Salusa Secundus; after receiving a tip, Desmond goes on a warpath to root out the insurgents; Tula tries to keep her secret project from being discovered.