A family of victims from a house fire is rushed to Gaffney; Lenox fights to save two sisters injured in an all-night rave turned tragedy; tensions mount between Goodwin and Abrams over difficult staffing changes.
Things get personal when Ripley and Archer butt heads over the treatment plans tied to an unusual case; Asher makes a surprising discovery with an expectant couple; a patient throws the hospital into chaos.
Lenox and Frost receive an unusual request from the parents of a patient on life support; Ripley and Charles work with a man who can't remember who he is.
Charles races to convince a patient to accept treatment before it's too late; Frost bonds with a young girl battling immunodeficiency; Lenox makes a chilling discovery.
A personal clash between Asher and Archer reaches a breaking point; Charles and Ripley uncover a rare neurological disorder in a patient; Goodwin's personal life is put to the test.
Charles grows increasingly suspicious of a colleague's intentions; Lenox crosses a line to protect a patient; Asher and Archer treat a soon-to-be father battling cancer.