A family of victims from a house fire is rushed to Gaffney; Lenox fights to save two sisters injured in an all-night rave turned tragedy; tensions mount between Goodwin and Abrams over difficult staffing changes.
Things get personal when Ripley and Archer butt heads over the treatment plans tied to an unusual case; Asher makes a surprising discovery with an expectant couple; a patient throws the hospital into chaos.
Lenox and Frost receive an unusual request from the parents of a patient on life support; Ripley and Charles work with a man who can't remember who he is.
Charles races to convince a patient to accept treatment before it's too late; Frost bonds with a young girl battling immunodeficiency; Lenox makes a chilling discovery.
Secrets are uncovered when Goodwin's family comes together for Bert; Ripley and Frost treat two children stung by hornets in a treehouse; a member of the team struggles with relationship woes.
Charles grows increasingly suspicious of a colleague's intentions; Lenox crosses a line to protect a patient; Asher and Archer treat a soon-to-be father battling cancer.
The doctors deal with the professional and personal fallout from the choices made during a city-wide power outage.
Tensions spike when a road rage incident sends three patients into the E.D.; Frost's former television co-star resurfaces; an unexpected arrival catches Hannah and Archer off guard.
Archer and Frost confront a troubling medical mystery while treating a college basketball player; Lenox's treatment of a surrogate patient leads to unexpected complications for the patient and her best friend.
Old resentment stirs up Charles when his best friends from med school visit; Asher is forced to overcome obstacles in the treatment of one of her patients; Ripley looks to honor his best friend, Sully, on the one-year anniversary of his death.
Charles faces a new challenge when three medical students shadow him for a day; Goodwin faces a high-stakes board meeting; Frost reckons with his past.