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When 18-year-old Lisa Monza is murdered in San Lorenzo, Calif., investigators look for a connection to other unsolved murders in the area.
After a respected widow is beaten to death in her Salt Lake City home, investigators suspect she knew her killer, but it will take 20 years before a set of children's fingerprints can put him at the scene of the crime.
A high school senior is murdered in her family's Minnesota farmhouse, but the case soon goes cold; years later, a fresh set of eyes spots an overlooked clue, but cold case detectives will need more to convict the killer.
A New Hampshire man is shot dead through his screen door; investigators are stumped until they uncover a seething grudge and a culprit closer to home than anyone could have imagined.
In southern Louisiana, a task force forms to hunt for a serial killer following a series of deadly home invasions.
The mutilated body of 17-year-old Lori Billingsley is found in a ditch on the outskirts of town, pointing to a sadistic killer on the loose in Oregon, but Billingsley's case goes cold, and it's up to her sister to pursue justice.
In Iowa, a pregnant 23-year-old woman is shot in her own bed, and investigators must determine if they are looking for someone with a deadly grudge or a culprit closer to home.
In Cleveland, 14-year-old Gloria Pointer is snatched off the street, assaulted and murdered on her way to school, and it will take detectives nearly 30 years to put her killer behind bars.
On her last day of school, a 14-year-old girl is brutally beaten and set on fire, sending shock waves through her California community.
The dumping of a woman's body prompts detectives to begin connecting the dots and find the link between seemingly random beatings, carjackings and murders.
Kimberly Dunkin's body is found with a single gunshot wound to the head, and though investigators suspect she was the victim of gang violence, it will take 15 years, a deck of playing cards and a lucky break before the case breaks.
Investigators must determine the identity of a murder victim whose skull was found on a highway in Florida.
Single mother Donna Kitowski heads to a Las Vegas supermarket late at night but never returns home, and soon the local TV news is reporting on a woman's near-lifeless body found in the desert..
Three blood-soaked dogs are the only witnesses to the brutal murder of Cathy Lamb in her Palm Beach, Fla., home, leaving detectives baffled by the gruesome crime scene.
During a slumber party, a man appears at 12-year-old Polly Klaas' bedroom door and abducts her at knife point.
The rape and murder of a 19-year-old journalism student in her bed is the latest in a string of unsolved homicides in a college town.
Police from three different states join the hunt for a serial rapist and murderer, known as the I-5 Killer, who is terrorizing communities along Interstate 5 on the West Coast.
A TV celebrity leads a major media campaign after a hardworking single mother is murdered in a Michigan town where violent crimes are nearly four times the national average.
In Kilgore, Texas, the residents are reeling from the execution-style slaying of five people abducted from a fast-food restaurant, and it will take several decades before the perpetrators are brought to justice.
After recording her first album, country singer Melissa Haferman is murdered and her body is dumped in a vacant lot near a bus depot in Louisville, Ky.
When a 20-year-old woman is gunned down in a Maryland suburb, the case goes cold with few leads and almost no evidence, and it will take 25 years before investigators finally close in on the killer.
After the mutilated body of 17-year-old Shauna Card is discovered on the bathroom floor in her Orlando, Fla., home, it will take years for investigators to finally crack the case.
Washington authorities are stunned when a mother of three dies from cyanide poisoning, and their murder investigation uncovers a pattern of tampering with boxes and blister packs.
A college student is stabbed to death while working the nightshift at a convenience store, and her murder goes unsolved for 10 years until an informant steps forward.
A beautiful young violinist is murdered at the venerable Metropolitan Opera House in Manhattan and the story becomes an international scandal; Police interview everyone behind the scenes and the search is on for the real Phantom of the Opera.
A Florida couple with a thriving business and a baby on the way are strangled to death in their home; detectives believe drug smuggling played a part in the crime.
A 14-year-old girl is brutally stabbed and raped while baby-sitting in an upscale community.
A woman's body is dumped alongside a road; a year later two more bodies are found at the side of the road.
Eighteen-year-old Amy Roman is found murdered in her Boston apartment, then the case goes cold, prompting her family members to undertake an investigation of their own.
A pillar of the Haitian community is gunned down in his driveway; the suspects include his second wife and mistress.
An unusual source is used to chase down a cold blooded killer after couple is shot in their home.
The execution style murder of a man in broad daylight appears to be a professional hit and to solve the crime, police search for murder weapon.
A woman is bludgeoned to death in her Arizona home; it takes 15 years for the police to catch the killer.
A grisly discovery provides clues in the disappearance of a flight attendant.