Jessica takes a teaching position in New York, gets an apartment and finds its previous tenant murdered.
A policeman-turned-professor challenges Jessica to solve a series of campus muggings that soon escalates to murder.
A friend (Bradford Dillman) is suspected of killing the author (Jessica Walter) who was writing an unauthorized biography of his wife.
Sheriff Metzger assumes his younger brother, the black sheep of the family, is guilty of murder, as charged.
New computer owner Jessica discovers hackers gathering information for blackmail, a crime that leads to murder.
Jessica probes a 20-year-old unsolved murder after attending the funeral of a New Orleans jazz great.
Jessica attempts to prove a battered wife innocent of killing her husband after failing to convince the woman to defend herself.
Jessica tries to disprove charges against her friend's boyfriend, suspected of murdering a Las Vegas casino manager.
After Jessica speaks at an exclusive men's club, they ask her to investigate when one of their members is murdered and they are all suspects.
Jessica finds herself amid international espionage while attending a trade reception in Washington, D.C.
Jessica is convinced that a ballerina who died during her premiere performance in a new ballet was actually murdered.
Cabot Cove suspects a woman (Mary Crosby) playing a witch in a community play is the real thing; guest Robert Vaughn.
The would-be producer (Ron Leibman) of the movie adaptation of Jessica's latest book dies, leaving Jessica to identify possible suspects.
While visiting an old friend (Dina Merrill) who runs a Monte Carlo hotel, Jessica investigates the murder of a ruthless businessman with numerous enemies.
While in London, Jessica becomes involved in a murder cover-up by the British Intelligence Agency when she happens upon a disappearing corpse.
After her husband (Kevin McCarthy) is murdered, an actress neighbor (Kate Mulgrew) involves Jessica in the investigation into the crime.
Jessica suspects a setup when her Irish colleague is charged with murdering his longtime nemesis, who is killed shortly after moving to the United States.
Jessica tries to clear Dr. Hazlitt after he is threatened with a possible malpractice suit when the owner of Cabot Cove's computer company dies.
While in Mexico City, Jessica researches two crimes when a mask stolen from the National Museum is found on the face of a murder victim.
Jessica is accused of false testimony and bribery in the death of an escaping murderer, and the man's daughter (Carrie Hamilton) takes Jessica to court.
When Jessica suffers a broken arm, she hires a typist to meet her deadline, but she must clear the woman of a murder charge.
Dennis Stanton (Keith Michell) tries to clear a man of charges he murdered an unscrupulous divorce attorney.
Jessica reopens a 16-year-old murder case at the urging of a dying author (Van Johnson) who felt injustice was done.
Jessica attends a political fundraiser with her friend Drew (Mike Farrell), but the focus turns to murder when another guest's chauffeur is murdered.
A physical-fitness instructor (Jason Beghe) who has captivated Cabot Cove's female population is linked to the murder of a con artist.
Jessica's first publisher (Arthur Hill), imprisoned for murder, is paroled and requires her help when he is suspected of a similar crime.
Jessica's friend Dennis Stanton (Keith Michell) is called to investigate when a purported Mark Twain manuscript leads to murder.
Jessica becomes enmeshed in feuds, infidelity and murder in Nashville when visiting her friend, blues singer Patti Sue Diamond (Florence Henderson), whose country-singer husband, Bobby (Jimmy Dean) is having trouble with his manager.
Insurance investigator Dennis Stanton confronts murder and arson while on a case involving a famous pianist (Ricardo Montalban).
Jessica and Seth inadvertently get entangled in a crime family's power struggle after a sniper attack in Boston wounds a mob boss.
Dennis Stanton (Keith Michell) investigates when he is accused of murdering his girlfriend's estranged husband.
Sheriff Metzger (Ron Masak) defies political pressure and arrests an ambassador's son for murder, then is accused of the crime.
A member of Jessica's fan club mysteriously dies while impersonating her to investigate cheating at a dog show.
Jessica's old friend (Phyllis Newman) is accused of murder when $2 million in tax payments disappears and her ex-husband is found dead.
Jessica and detective Harry McGraw (Jerry Orbach) investigate the murder of a Thoroughbred owner whose prize horse has sired two unplanned foals.
The presumed-dead perpetrator (Donnelly Rhodes) of a 20-year-old bank robbery resurfaces, then is murdered.
Insurance investigator Dennis Stanton becomes involved in a murder case while delving into the disappearance of a shy ventriloquist's (Grant Shaud) dummy.
Jessica is pulled into a murder investigation by a woman (Vera Miles) who claims Jessica's husband fathered her son.
Jessica comes to the aid of a small-town diner's owner (Dee Wallace Stone), who becomes an outcast when she is blamed for three arsenic poisoning deaths.
A writer is murdered after sending Jessica a manuscript exposing a kidnapping scam, and Jessica's friend, private investigator Harry McGraw (Jerry Orbach) is caught near the body.
One of Jessica's former students (Diana Canova), a script writer for a TV show, must find the killer of a network executive or look for another job.
Jessica's old friend, NYPD Detective Lt. O'Malley (Pat Hingle), investigates the suspicious suicide of a wealthy New York developer's wife.
While Jessica is in Texas to attend her cousin Ann's wedding, the bridegroom is murdered, as was Ann's first fiance 15 years earlier.
Jessica's nephew and his wife enjoy housesitting in Cabot Cove until they discover the body of a peg-legged murder victim on the living room floor.
Michael Haggerty (Len Cariou) falls for a widow (Deidre Hall) whose volatile brothers-in-law pose a threat.