The First 48: Missing Persons
When a person goes missing, the first 48 hours are the most crucial in an investigation.
Desperate Measures; The Big City
S2 E2
A missing mother of four leaves behind a suicide note; a detective searches for a disoriented woman wandering the streets of Chicago.
In the Wind
S2 E3
Detectives probing a dental student's disappearance turn their focus on the victim's husband and mother, but the investigation stalls after both pass their polygraph tests.
Deleted; Cruel Streets
S2 E4
An online predator may be behind the disappearance of an aspiring model; police race to locate a mentally disabled man before he becomes a victim of street violence.
Lost Anniversary; Checked Out
S2 E5
A woman reports her husband missing the day after their second wedding anniversary; a missing hotel guest is spotted on surveillance video leaving the establishment.
Family Matters
S2 E6
Police detectives investigate the subculture of Chicago's black gay males when a young man leaves a disturbing voice mail message and then goes missing.
3:10 to Yuma; Harm's Way
S2 E7
A man reports that his missing girlfriend left him an ominous phone call; a Chicago teenager falls under the influence of a gang member considered to be armed and dangerous.
The Good Mother
S2 E8
Detectives search for an elderly woman who vanished after returning from a doctor's appointment, with the suspicion that the use of pain medication may have contributed to her disappearance.
Critical Care
S1 E2
Caretaker reports her 63-year-old cancer patient is missing; a missing mattress may solve the case.
Taken; Scorcher
S1 E4
Detectives search for a 14-year-old girl who was snatched by an older teen with possible gang connections; an elderly man with serious neurological problems goes missing.
Worried Sick; Silent Night
S1 E5
A 17-year-old teen and her child are missing; an elderly man vanishes en route to a Christmas party.
Mother's Day; Somebody Knows
S1 E6
The children of an Iraqi immigrant worry she is trying to return to Baghdad; daughters fear their mother was a victim of foul play.
The Graduate
S1 E7
A talented man vanishes on his bicycle; detectives must untangle the past to uncover the truth.