Police suspect that one man may be responsible for the disappearances of two women and their young children.
Detectives probing a dental student's disappearance turn their focus on the victim's husband and mother, but the investigation stalls after both pass their polygraph tests.
An online predator may be behind the disappearance of an aspiring model; police race to locate a mentally disabled man before he becomes a victim of street violence.
A woman reports her husband missing the day after their second wedding anniversary; a missing hotel guest is spotted on surveillance video leaving the establishment.
Police detectives investigate the subculture of Chicago's black gay males when a young man leaves a disturbing voice mail message and then goes missing.
A man reports that his missing girlfriend left him an ominous phone call; a Chicago teenager falls under the influence of a gang member considered to be armed and dangerous.
Detectives search for an elderly woman who vanished after returning from a doctor's appointment, with the suspicion that the use of pain medication may have contributed to her disappearance.
Caretaker reports her 63-year-old cancer patient is missing; a missing mattress may solve the case.
A missing man's life is under threat; a missing teenager has a rare sleep disorder.
Detectives search for a 14-year-old girl who was snatched by an older teen with possible gang connections; an elderly man with serious neurological problems goes missing.
A 17-year-old teen and her child are missing; an elderly man vanishes en route to a Christmas party.
A talented man vanishes on his bicycle; detectives must untangle the past to uncover the truth.