After making his escape from the FBI, Hannibal travels through Europe with Bedelia Du Maurier; flashbacks reveal details about Hannibal and Bedelia's relationship.
Will heads to Europe in search of closure with Lecter; in Italy, Will draws suspicion from an inspector who believes Lecter and a killer he pursued 20 years earlier are one in the same.
Will travels to Hannibal's childhood home in Lithuania, where he meets a mysterious woman (Tao Okamoto); Jack hopes to find Will before tragedy strikes; Bedelia has a warning for Hannibal.
Having survived a disfiguring gunshot, Dr. Fredrick Chilton focuses on using Will as bait to catch Hannibal; distracted by Bella's failing health, Jack begs Will to give up on finding Hannibal.
The offer of riches from Mason Verger threatens to put Inspector Pazzi off his quest for redemption; Will and Chiyoh travel to Florence in search of Hannibal; Alana Bloom worries for everyone's safety.
Captured in Italy, Hannibal and Will are brought to Muskrat Farm, where Mason awaits; Alana plots Will's rescue; Margot is reminded that Mason never keeps his promises; Chiyoh learns of Hannibal's location.
Jack Crawford approaches Will to help catch a serial killer, known as the Tooth Fairy, who is targeting families.
As the search for Francis Dolarhyde (Richard Armitage) continues, Will starts imagining himself in Dolarhyde's tormented psyche -- and asks Hannibal for help with the serial killer's profile; a new woman (Rutina Wesley) enters Dolarhyde's life.
Carvings retrieved from crime scenes help Will and the FBI learn about Francis Dolarhyde's psychology; Dolarhyde finds a way to communicate with Hannibal.
With a full moon approaching, Jack and Will are certain that Francis Dolarhyde will strike again but they lack a solid lead; Alana gives Hannibal a chance for redemption.
The FBI enlists the help of Dr. Fredrick Chilton in hope of drawing Francis Dolarhyde into an ambush; Will's empathy for Dolarhyde impacts his psyche.
Will orchestrates a plot involving Hannibal in hope of slaying Francis Dolarhyde; Bedelia is concerned for Will and the lives of those close to him.
While Will continues to assert his innocence, Hannibal and Jack try to come to terms with the fact that he's in jail; Kade Purnell visits Will.
The body of one of Hannibal's victims turns up, carrying valuable evidence for the team; Will works to prove his innocence; Jack submits to mandated therapy; Will has an unexpected visitor.
Will watches as his trial forces those closest to him to choose sides; a court bailiff appears to have been murdered by a copycat killer.
When a body is discovered in a meadow, the cranial cavity appears to have been turned into a beehive; Beverly secretly consults with Will on the mural killer case.
When Will assists with a profile he reveals the Chesapeake Ripper and the Copycat Killer are the same person; Will asks Freddie Lounds to help him contact his admirer; Alana becomes suspicious of Will.
A city councilman's body is found intertwined with a tree; Jack crashes Hannibal's dinner party to investigate Will's suspicions; a revelation shocks everyone.
When Miriam Lass is found alive, evidence at her rescue site exonerates Will; Dr. Chilton (Raúl Esparza) tries to confide in Jack but is rebuffed.
Will helps investigate the case of a woman's body found inside of a horse; Alana worries about Will's intentions toward Hannibal; Will and Hannibal rush to protect a witness they believe to be in danger.
A truck driver's body appears to have been torn apart by two different species of animals working in tandem; Will meets Hannibal's new patient; Hannibal sends Will a test to determine his true self.
Will's readiness to go to dark places strengthens his bond with Hannibal -- and garners Jack's attention; Hannibal gives Margot advice about her brother's violent nature.
During a therapy session, Will shares a vision of how he would kill Hannibal; feeling impatient, Jack brings in a surprise witness to help Will catch Hannibal.
Will ties up loose ends as he wonders if he will survive the trap he has set for Hannibal; loyalties are tested.
As the FBI investigates the disappearance of college students, Jack Crawford recruits a criminal profiler, Will Graham, and a brilliant psychiatrist, Dr. Hannibal Lecter -- who is secretly a serial killer and a cannibal.
Will Graham helps Jack Crawford search for a killer who buries his victims alive to grow mushrooms; Will, starting to trust Hannibal, opens up about killing Hobbs; Freddie Lounds lurks around the investigation.
Jack thinks Abigail might have helped her father -- a serial killer -- with his crimes; Hannibal encourages Abigail to return to Minnesota.
A group of missing children are brainwashed into killing their families; Hannibal checks Abigail out of the hospital.
Will and the team track a serial killer who has a gruesome ritual; Hannibal tries to drive a wedge between Jack and Will; Jack's wife, Bella, starts therapy with Hannibal.
Alana and Jack are contacted by a former colleague who thinks he has the Chesapeake Ripper in custody; Jack opens up to Hannibal.
A murder involving organ removal makes Jack think that the Chesapeake Ripper has resurfaced; Will has nightmares about being a killer; Hannibal tries to seduce Alana Bloom.
The team hunts a killer who makes a totem pole out of his victims' corpses; Jack and Alana question Abigail about Nick Boyle's death; when Abigail agrees to write a book with Freddy Lounds, she reveals a secret to Hannibal.
Will contaminates a crime scene; Hannibal convinces Dr. Sutcliffe to keep a diagnosis of encephalitis from Will; Will's team questions his claim of having seen a woman at the crime scene.
The BAU team searches for Dr. Gideon, who has escaped custody and intends to kill psychiatrists who have profiled him; Hannibal misleads the team in order to get Will and Gideon in the same room; Jack questions Dr. Chilton about Gideon's escape.
The BAU team finds evidence linking Abigail to the Minnesota Shrike victims; Will checks Abigail out of the hospital; Hannibal convinces Jack that Will is capable of murder.
Will returns from Minnesota without Abigail, and the BAU team finds evidence that he killed her.