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Akira finds himself being chased by hordes of undead when a zombie pandemic breaks out.
Seeking to reclaim three years' worth of unused vacation time, Akira spends his days being lazy, day drinking and ignoring the chaos happening in the world; unfortunately, he's down to his last beer.
Akira's made his way to Shinjuku to see Kencho, the only friend he's still in touch with. Kencho went on to become a successful member of society, but now finds himself in a life-or-death situation. Will Akira be able to save Kencho?!
Akira and Kencho take a trip to Ikebukuro to snag a big-screen TV.
Akira bids farewell to Tokyo and starts the journey back to his hometown, Gunma; but first, he stops by a showroom in Saitama to get an RV.
With only a little farther to go until they reach Akiras hometown in Gunma, the gang runs into a German college student named Beatrix, who slices through a zombie with a naginata while wearing samurai armor.
With the only tunnel to the village sealed off, Akira and the others decide to cut through the forest and cross the mountain; along the way, they run into a man named Kumano, who is constructing a treehouse in the forest.
Together with the villagers and the people who escaped from Tokyo, Akira and his friends help each other out while enjoying a brief moment of happiness; meanwhile, Higurashi has been preparing to take his revenge on society.
Akira and his friends split up to save the villagers from the massive swarm of zombies; but zombies aren't their only concern as Higurashi and his gang stand in their way; Teruo manages to stop the zombies by himself, but he is captured by Higurashi.
In order to save his father, Akira has to become a zombie. Faced with the ultimate choice, what will he choose to do? Will Akira and his friends have to give up on their list of 100 things they want to do before becoming zombies?