After a series of women in the Seattle area are found brutally murdered with their bodies posed, police realize that they might have a killer stalking the area nightclub scene who is able to charm his victims into submission.
Chicago police investigate the murders of several women, whose bodies are discovered in abandoned buildings barefoot.
Chicago detectives believe that a serial killer is using classified ads to lure and murder his victims.
A killer crisscrosses the Midwest leaving a string of victims along the interstate, but when he realizes investigators are hot on his trail the murderer suddenly changes his mark.
A cold-blooded killer conceals his victims' bodies with trash, discarding them like garbage in the back alleyways of Los Angeles.
A Houston killer taunts the media and authorities as he uses homemade ligatures to murder his victims.
El Paso investigators race to track down a ruthless killer who is burying his victims in shallow desert graves, dead or alive.
Chaos descends on Phoenix as two serial killers compete for the media's attention and the bodies pile up faster than the police can investigate.
Investigators in East Baton Rouge, La., hunt for a serial murderer who carefully carves up and cuts the bodies of his victims after death.
Minnesota police hunt for a killer caller who confesses to a string of murders in a chilling, high-pitched voice, begging for forgiveness; no one can identify him until one woman survives a brutal attack.
In the summer of 1976, the NYPD are chasing a man shooting at couples in parked cars with a gigantic, .44 caliber handgun; he taunts the city with terrifying letters until police get a lead about a suspect who has shot a neighbor's dog.
Brooklyn shopkeepers are afraid of closing time as a killer shoots his victims while locking up their stores.
In the 1990s, New York is on edge as a killer leaves coded clues at crime scenes and declares his compulsion to choose victims by their birth signs.
A rash of young men goes missing around Chicago during the 1970s; when bodies start washing up in the river, a pattern emerges; a small piece of evidence leads police to the home of a model citizen, where his furnace puts the suspect in the hot seat.
Numerous women are found dead by the side of the road with a unique ligature that looks like a dog collar and leash; detectives are stumped until a 17-year-old girl manages an escape from a vicious kidnapper, leading police to a serial killer.
The I-5 corridor in California is taken over by a brazen bandit who terrorizes the highway with a blitz of assaults and murders; the only clue to the killer's identity is a specific athletic tape used to bind his victims.
A serial killer taunts Wichita, Kan., for decades by sending brazen letters and taking credit for horrific kills; at the introduction of the computer era, the killer gets sloppy and accidentally leaves a digital clue.
In the 1990s, Louisiana is terrorized by multiple serial killers; the Zachary Police Department discovers the key to solving their cases when a pattern emerges with personal items missing from each local victim.
In 1990, a serial killer terrorizes the University of Florida's campus, killing five students in under four days; the Gainesville Ripper leaves behind a crime scene where all the victims have been stabbed but the females have been posed like dolls.
In New Jersey four bodies are found dismembered, bagged, and thrown in roadside garbage cans; the "Last Call Killer" hunted his victims openly in piano bars but no one suspected he could be hiding in plain sight, working as a local nurse.
Dallas police discover three women murdered with their eyes surgically removed; police believe they have a deranged doctor on the loose until two rookie cops find themselves on the trail of a man with a talent for taxidermy and a hatred for women.
A killer hijacks the highways of Sacramento as several women are found strangled with their clothing cut into precise but odd patterns; a survivor leads police to a sports car driving deviant posing as a good samaritan to poach potential victims.
Texas authorities have a killer riding the rails and leaving a literal trail of bread crumbs after eating at victims' tables; when more murders are linked, the FBI names a Most Wanted suspect and a national manhunt for The Railroad Killer ensues.